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صفحه اصلی مقالات Exercise And Homocysteine Levels In Coronary Artery Disease

Exercise And Homocysteine Levels In Coronary Artery Disease

Abstract
Back ground: elevated plasma homocysteine levels are a risk factor for coronary artery disease, but the prognostic value of homocysteine levels in patients with established coronary artery disease has not been defined.
Methods:
we prospectively investigated the relation between plasma total homocysteine levels and mortality among 60 patients with angiographically confirmed coronary artery disease. At the time of angiography in 2005 or 2008, risk factors for coronary disease, including homocysteine levels were evaluated. The majority of the patients subsequently underwent exercise and drugs 30 patients (50%) percutaneous transluminal coronary angioplasty 20% and coronary - artery by pass grafting 30%.
Results:
After a median follow – up of 3 years all the patients underwent regular exercise loss of 2200 kcal /week, diet, weight reduction, L.Arginine, angiotension converting enzyme inhibitor (ACEI), statin had alived. we found a strong , graded relation between plasma homocysteine levels and over all mortality.
After 2 years, %3.8 of patients with homocysteine levels below 9 µ mol/lit had died, as compared with %30 of those with homocysteine levels of 15 µ mol/lit or higher.
All the patients came to our program, regular exercise (2200 k/cal/week) after 3 months, homocysteines levels came below 9 ± 3 µ mol/l. we managed, regular exercise with respect to extent previous myocardial infarction, the left ventricular ejection fraction and cardiac output, stroke volume, vo2 max (volume of maximum o2 uptake in 12 minutes) and (BMI) body mass index. The relation of homocysteine levels to mortality remained strong after adjustment for these and other potential confounders. In an analysis in which the patients with homocysteine levels below 9 µ mol/lit were used as exercise group no mortality ratios were found, 2.8 for those with levels of 15.0 to 19.9 µ mol/lit and 4.5 for those with levels of 20.0 µ mol/lit or higher. When death due to cardiovascular disease was used as the end point in the analysis, the relation between homocysteine levels and mortality was slightly strengthened.